Monday, December 23, 2019
A Brief Note On Atherosclerosis And Its Effects On The...
1. MYOCARDIAL INFARCTIONS Atherosclerosis impairs proper perfusion through ischemia and has acute and long-term serious consequences on the bodyââ¬â¢s vasculature including unstable and stable angina, myocardial infarctions, sudden cardiac death, transient ischemic attacks, cerebrovascular disease and more. The most common cause of myocardial infarctions (MI) is ischemic heart disease, and in turn, MIs are one of the leading causes of heart failure because they directly alter the structure and function of the heart. Heart failure can be described as the inability of the heart to adequately fill or contract in order to meet the bodyââ¬â¢s metabolic demands. MIs affect the ability of the heart to properly fill and eject blood depending on the location and extent of infarct. The adrenergic response and renin-angiotensin aldosterone system (RAAS) both play a vital role in the regulation of heart rate and stroke volume. In the short-term, the death of myocardial cells due to occlusion and lack of oxygen and nutrients leads to overall decreased muscle cells, decreased stroke volume, and thus decreased cardiac output. Following an MI, cell death, inflammation, and neurohormonal mechanisms contribute to cardiac remodeling which has long-term detrimental consequences. Initially, persistent ischemia directly leads to cardiomyocyte loss from necrosis and apoptosis. Furthermore, inflammatory cells and their mediators such as the pro-fibrotic cytokines TGF-B1 and CTGF begin to clear necroticShow MoreRelatedA Brief Note On Atherosclerosis And Its Effects On The Heart Essay1138 Words à |à 5 Pagesof the disease Atherosclerosis is a disease dealing with the heart. This disease causes hardening and narrowing (or even blockage) of the arteries, which makes the arteries thicken. Accumulations of fat, calcium and plaque build up are all components of having this disease known as atherosclerosis. 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